Health Research Projects in Tollers
The Bannasch Laboratory at the School of Veterinary Medicine, University of California Davis has two projects ongoing in the NSDTR for which samples are being collected.
Project 1. Addison's disease: The laboratory has continued the work
initiated through funding by the Canine Health Foundation and the NSDTR
Donor advised fund on identifying the mutation that causes Addison's
disease in the NSDTR. Samples are still being actively being collected to narrow the search for the causative mutation. Contact Dr. Bannasch (530) 754-8728
Project 2. Cleft lip and cleft palate: Dr. Bannasch and Dr. Wade
(University of Sydney) have recently received NIH funding for research
on the genetic cause of cleft palate and cleft lip in the NSDTR.
Samples are being collected from affected puppies. Contact Zena Wolf for more information.
Project 3. The genetic test for Buff in the NSDTR has been validated and is available at the Veterinary genetics Laboratory, University of
The test is called "Dilute"
Cleft Palate in Tollers
University of California-Davis & University of Sydney in Australia
- Contact Health & Genetics Chair for more information.
- HEALTH AND GENETICS REPORT - November 2008 (PDF); Article provides information on samples needed.
- As a side note, there has been no thorough exploration of palate morphology in the Tollers so far, so if you have a dog that is being anaesthetized for other purposes it would be great if you could ask your veterinarian to take a digital photo of the back edge of the palate for us (You will probably have to provide the camera). It is nearly impossible to view this in a dog that is awake.
Addison's Study-Genome Scan
National Institutes of Health - Ostrander Lab
- Study being conducted on Tollers and Portuguese Water Dogs.
- Blood samples being sought from Tollers diagnosed with Addison's as well as healthy older controls.
- Any owner wishing to take part will be asked to complete a brief consent form, blood sample and pedigree.
- Contact Health & Genetics Chair or Donna Viglietti, Lab Samples Manager, at NIH for more information.
- HEALTH AND GENETICS REPORT - November 2008 (PDF) - Updated August 2009
Addison's DNA Study in Tollers
University of California - Davis
01233-A: Examining Hypoadrenocorticism in Nova Scotia Duck Tolling Retrievers Utilizing Whole Genome SNP Association
Grant Status: Closed
Grant Amount: $12,862
Dr. Danika L Bannasch, DVM PhD, University of California, Davis
June 1, 2009 - May 31, 2010
Sponsor(s): Nova Scotia Duck Tolling Retriever Club (USA)
Breed(s): Nova Scotia Duck Tolling Retriever
Addison's disease in the NSDTR has a complicated presentation. Dogs have
been diagnosed as early as 7 weeks of age and as old as 11 years. In
some cases, other diseases are seen in conjunction with Addison's
disease like megaesophagus, hypothyroidism and eye problems. The
sequencing of the canine genome has made available some powerful new
tools for the investigation of inherited diseases. One of those sets of
tools is SNP arrays that can test thousands of markers at one time.
Recently, Illumina inc. developed an expanded canine SNP array that can
test 173,000 markers at once. We utilized this array to investigate
Addison's disease in the NSDTR by comparing markers between affected and
unaffected dogs. A significantly associated chromosomal region was
identified using this approach. In the future we will evaluate genes in
this region for mutations associated with Addison's disease so that a
DNA-based test can be offered to breeders.
- Summary Report from Dr. Hughes - January 2005. (PDF)
- UPDATE – UC DAVIS ADDISON’S STUDY IN TOLLERS - August 2006 (PDF)
Skeletal Dysplasia & Chondrodysplasia in Multiple Breeds
University of California - Davis
- October 2009 - This study has concluded.
- Tollers are included in this study, and the study has received funding from the Canine Health Foundation.
- For more information about the condition and to see a picture of a Toller with skeletal dysplasia, go to: http://faculty.vetmed.ucdavis.edu/faculty/dlbannasch/lab/projects/sd.htm
- Summary Report from Dr. Bannasch - October 2004 (PDF)
To benefit Tollers, please consider making a tax deductible donation to the
AKC Canine Health Foundation's NSDTR Donor Advised Fund